| Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL-12p70 production in dendritic cells. | |
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MedLine Citation:
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PMID: 20500695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human herpesvirus 6B (HHV-6B) is the causative agent of the common childhood febrile illness, exanthema subitum. The virus is predominantly regarded as a T-cell tropic virus, although in reality it has the ability to infect a wide variety of cell types including monocytes, macrophages and dendritic cells (DC). Although DC are important immune regulators, the modulating effects of HHV-6B on DC are controversial. Here, we examine the phenotypic and functional consequences of HHV-6B infection of DC. The addition of HHV-6B to immature DC led to expression of the nuclear viral p41 protein and cell surface expression of the viral glycoprotein gp60/110 consistent with HHV-6B infection. Nevertheless, HHV-6B did not induce noticeable cytopathogenic effects or cell death in infected DC. Importantly, HHV-6B infection induced a partial phenotypic maturation of immature DC as demonstrated by a substantial increase in the expression of HLA-DR, CD86 and CD40, whereas only a minor increase in CD80 and CD83 was observed. This phenotypic maturation was, however, not followed by functional maturation, because HHV-6B infection did not induce IL-10 and IL-12p70 production in immature DC. However, infected DC were still able to react to bacteria-derived stimuli such as lipopolysaccaharide by an even more pronounced production of IL-10 and IL-12p70 when compared to that of uninfected DC. |
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Authors:
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L B Bertelsen; C C Petersen; E Kofod-Olsen; B Oster; P H?llsberg; R Agger; M Hokland |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 71 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 431-9 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology and Immunology, Aarhus University, Aarhus C, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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immunology Antigens, CD40 / immunology Antigens, CD80 / immunology Antigens, CD86 / immunology Dendritic Cells / immunology*, ultrastructure, virology* Enzyme-Linked Immunosorbent Assay Flow Cytometry HLA-DR Antigens / immunology Herpesvirus 6, Human / immunology* Humans Immunoglobulins / immunology Immunophenotyping Interleukin-10 / biosynthesis*, immunology Interleukin-12 / biosynthesis*, immunology Membrane Glycoproteins / immunology Microscopy, Confocal Roseolovirus Infections / blood, immunology*, virology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD40; 0/Antigens, CD80; 0/Antigens, CD86; 0/CD83 antigen; 0/HLA-DR Antigens; 0/Immunoglobulins; 0/Membrane Glycoproteins; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12 |
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