Document Detail

Human Gut Flora-Fermented Non Digestible Fraction from Cooked Bean (Phaseolus vulgaris L.) Modifies Protein Expression Associated with Apoptosis, Cell Cycle Arrest and Proliferation in Human Adenocarcinoma Colon Cancer Cells.
MedLine Citation:
PMID:  23194196     Owner:  NLM     Status:  Publisher    
Metabolism of non digested fraction (NDF) from common bean (Phaseolus vulgaris L.) by the human gut flora (hgf) produces short chain fatty acids (SCFAs) that may benefit cancer by reducing colorectal tumor risks. We report the effect of fermentation products (FP) by hgf (FP-hgf) from NDF of cooked beans on survival and protein expression associated with apoptosis, cell cycle arrest and proliferation in human adenocarcinoma colon cancer cells. FP-hgf was the only inoculum eliciting butyrate production after 24 h NDF fermentation using different bacterial sources. FP-hgf inhibited HT-29 cell growth and modulated protein expression associated with apoptosis, cell cycle arrest and proliferation, as well as morphological changes linked to apoptosis evaluated by TUNEL and hematoxylin & eosin stains confirming our previous results on gene expression. Current results suggest that fermentation of NDF from common beans can elicit beneficial chemoprotective effects in colon cancer by modulating protein expression in HT-29 cells.
Rocio Campos-Vega; Teresa Garcia-Gasca; Ramon Guevara-Gonzalez; Minerva Ramos-Gomez; B Dave Oomah; Guadalupe Loarca-Pina
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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