Document Detail

The human genome and sport, including epigenetics, gene doping, and athleticogenomics.
MedLine Citation:
PMID:  20122459     Owner:  NLM     Status:  MEDLINE    
Hugh Montgomery's discovery of the first of more than 239 fitness genes together with rapid advances in human gene therapy have created a prospect of using genes, genetic elements, and cells that have the capacity to enhance athletic performance (to paraphrase the World Anti-Doping Agency's definition of gene doping). This brief overview covers the main areas of interface between genetics and sport, attempts to provide a context against which gene doping may be viewed, and predicts a futuristic legitimate use of genomic (and possibly epigenetic) information in sport.
N C Craig Sharp
Related Documents :
15218539 - Molecular mediators, environmental modulators and experience-dependent synaptic dysfunc...
17407749 - On the use of the word 'epigenetic'.
16088349 - 10 years of the nisin-controlled gene expression system (nice) in lactococcus lactis.
19850149 - Forkhead transcription factors in chronic inflammation.
16701349 - Candidate genes for behavioural ecology.
12730129 - Genetics of human laterality disorders: insights from vertebrate model systems.
24910339 - Influence of setup and carbon source on the bacterial community of biocathodes in micro...
1624089 - Tissue-specific sensitivity of chromatin and the vitellogenin gene to micrococcal nucle...
21408209 - A bow-tie genetic architecture for morphogenesis suggested by a genome-wide rnai screen...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-15, xi     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, West London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apolipoproteins E / genetics
Doping in Sports / methods*,  prevention & control
Epigenesis, Genetic* / genetics,  physiology
Erythropoietin / genetics
Fatigue / genetics
Fatigue Syndrome, Chronic / genetics
Gene Therapy / adverse effects
Gene Transfer Techniques* / adverse effects
Genetic Predisposition to Disease
Genome, Human*
Insulin-Like Growth Factor I / genetics
Myostatin / genetics
Peptidyl-Dipeptidase A / genetics
Receptors, Erythropoietin / genetics
Sex Determination (Analysis)
Sports / physiology*
Reg. No./Substance:
0/Apolipoproteins E; 0/Myostatin; 0/Receptors, Erythropoietin; 11096-26-7/Erythropoietin; 67763-96-6/Insulin-Like Growth Factor I; EC A; EC 3.4.17.-/angiotensin converting enzyme 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Training Modalities: Impact on Endurance Capacity.
Next Document:  A Contemporary Comparison of Aortofemoral Bypass and Aortoiliac Stenting in the Treatment of Aortoil...