Document Detail


The human genome and sport, including epigenetics, gene doping, and athleticogenomics.
MedLine Citation:
PMID:  20122459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hugh Montgomery's discovery of the first of more than 239 fitness genes together with rapid advances in human gene therapy have created a prospect of using genes, genetic elements, and cells that have the capacity to enhance athletic performance (to paraphrase the World Anti-Doping Agency's definition of gene doping). This brief overview covers the main areas of interface between genetics and sport, attempts to provide a context against which gene doping may be viewed, and predicts a futuristic legitimate use of genomic (and possibly epigenetic) information in sport.
Authors:
N C Craig Sharp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-15, xi     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, West London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins E / genetics
Doping in Sports / methods*,  prevention & control
Epigenesis, Genetic* / genetics,  physiology
Erythropoietin / genetics
Fatigue / genetics
Fatigue Syndrome, Chronic / genetics
Female
Gene Therapy / adverse effects
Gene Transfer Techniques* / adverse effects
Genetic Predisposition to Disease
Genome, Human*
Humans
Insulin-Like Growth Factor I / genetics
Male
Myostatin / genetics
Peptidyl-Dipeptidase A / genetics
Receptors, Erythropoietin / genetics
Sex Determination (Analysis)
Sports / physiology*
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Myostatin; 0/Receptors, Erythropoietin; 11096-26-7/Erythropoietin; 67763-96-6/Insulin-Like Growth Factor I; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.-/angiotensin converting enzyme 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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