Document Detail


Human exposure to particulate matter potentially contaminated with sin nombre virus.
MedLine Citation:
PMID:  23532351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most common mechanism for human exposure to hantaviruses throughout North America is inhalation of virally contaminated particulates. However, risk factors associated with exposure to particulates potentially contaminated with hantaviruses are generally not well understood. In North America, Sin Nombre virus (SNV) is the most common hantavirus that infects humans, causing hantavirus pulmonary syndrome, which has a significant mortality rate (approximately 35%). We investigated human exposure to particulate matter and evaluated the effects of season, location (sylvan and peridomestic environment), and activity (walking and sweeping) on generation of particulates at the breathing zone (1.5 m above the ground). We found greater volumes of small inhalable particulates during the spring and summer compared to the fall and winter seasons and greater volumes of small inhalable particulates produced in peridomestic, compared to sylvan, environments. Also, greater volumes of particulates were generated at the breathing zone while walking compared to sweeping. Results suggest that more aerosolized particles were generated during the spring and summer months. Our findings suggest that simply moving around in buildings is a significant source of human exposure to particulates, potentially contaminated with SNV, during spring and summer seasons. These findings could be advanced by investigation of what particle sizes SNV is most likely to attach to, and where in the respiratory tract humans become infected.
Authors:
Kyle S Richardson; Amy Kuenzi; Richard J Douglass; Julie Hart; Scott Carver
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  EcoHealth     Volume:  10     ISSN:  1612-9210     ISO Abbreviation:  Ecohealth     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2014-02-18     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  101222144     Medline TA:  Ecohealth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Reservoirs / virology
Environment
Feces / virology
Hantavirus Pulmonary Syndrome / transmission*,  virology
Humans
Inhalation Exposure / adverse effects*,  analysis
Mice
Montana
Particulate Matter / adverse effects*,  analysis
Peromyscus / virology
Rodent Diseases / transmission,  virology
Seasons
Sin Nombre virus / isolation & purification*,  pathogenicity
Zoonoses* / transmission,  virology
Grant Support
ID/Acronym/Agency:
5P20RR016455-11/RR/NCRR NIH HHS; 8 P20 GM103474-11/GM/NIGMS NIH HHS; P20 GM103474/GM/NIGMS NIH HHS; P20 RR016455/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Particulate Matter
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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