| Human EAG1 Potassium Channels in the Epithelial-to-Mesenchymal Transition in Lung Cancer Cells. | |
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MedLine Citation:
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PMID: 21508374 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Human ether à go-go-1 (EAG1) potassium channels are potential tools for cancer diagnosis, prognosis and therapy. Epithelial-to-mesenchymal transition (EMT) is a likely mechanism by which tumor cells become malignant. We wondered whether EAG1 is regulated in human lung tumor cells undergoing EMT. MATERIALS AND METHODS: EMT was induced in A549 lung tumor cells with transforming growth factor beta (TGFβ1). EAG1 gene expression was assesed by real-time RT-PCR and protein expression by flow cytometry. RESULTS: TGFβ1 produced the expected changes in morphology, migration and gene expression associated to EMT. EAG1 gene and protein expression were up-regulated during EMT. Astemizole did not prevent EMT. CONCLUSION: Our results suggest that EAG1 channels participate in the acquisition of a malignant phenotype in lung tumor cells. Their potential role in EMT might not be uniquely related to their conducting function, in accordance with the reported tumor growth supported by non-conducting EAG1 channels. |
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Authors:
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Iván Restrepo-Angulo; Carmen Sánchez-Torres; Javier Camacho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1265-70 Citation Subset: IM |
Affiliation:
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Center for Research and Advanced Studies, I.P.N., Department of Pharmacology, Av. Instituto Politécnico Nacional 2508, Mexico City, 07360. Mexico. fcamacho@cinvestav.mx. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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