| Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. | |
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MedLine Citation:
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PMID: 20632887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mechanisms underlying the onset and perpetuation of chronic immune activation in individuals without overt infectious or autoimmune diseases are unclear. Cytomegalovirus (CMV) is a persistent virus that induces a permanent increase of highly differentiated, interferon-gamma-secreting effector T cells. We hypothesized that, because of this increase, CMV also induces a systemic inflammatory response. We measured acute phase proteins, cytokines, and chemokines in serum samples from renal transplant recipients who developed a primary CMV infection and healthy CMV serum-positive or -negative individuals. Primary CMV infection induced a clear proinflammatory response that was maintained during latency. This response was characterized by increased levels of acute phase proteins, such as serum amyloid-A and C-reactive protein, and type 1 cytokines, such as interleukin-18, interferon-inducible protein-10, and interferon-gamma. This continuous activation of the immune system may play a role in the pathogenesis of chronic allograft rejection and potentially contribute to the acceleration of chronic diseases. |
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Authors:
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Pablo J van de Berg; Kirstin M Heutinck; Robin Raabe; Robert C Minnee; Si La Young; Karlijn A van Donselaar-van der Pant; Frederike J Bemelman; Rene A van Lier; Ineke J ten Berge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 202 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 690-9 Citation Subset: AIM; IM |
Affiliation:
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Renal Transplant Unit, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands. p.j.vandeberg@amc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult C-Reactive Protein / metabolism Cytokines / metabolism* Cytomegalovirus / immunology*, physiology Cytomegalovirus Infections / immunology*, virology Female Humans Interferon-gamma / metabolism Interleukin-18 / metabolism Kidney Transplantation / adverse effects Male Middle Aged Th1 Cells / immunology*, metabolism Virus Latency |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-18; 82115-62-6/Interferon-gamma; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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