| Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. | |
| | |
MedLine Citation:
|
PMID: 23077239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have previously shown that NKG2C(+) NK cells from CMV naive umbilical cord blood grafts expand preferentially in recipients after CMV reactivation, representing a primary NK cell response after hematopoietic cell transplantation. In this study, recipients of adult donor hematopoietic cell transplantation were assessed to evaluate the role of donor/recipient CMV serostatus on the expression and function of NKG2C(+) NK cells to determine responses to secondary CMV events. Expansion of NKG2C(+) NK cells was seen following clinical CMV reactivation. However, they also expanded in the absence of detectable CMV viremia when both the donor and recipient were CMV seropositive. Upregulation of NKG2C was observed in NK cells from CMV-positive recipients receiving grafts from CMV-seropositive or -seronegative donors. These in vivo-expanded NKG2C(+) NK cells had an increased capacity for target cell-induced cytokine production, expressed an inhibitory killer Ig-like receptor for self-HLA and preferentially acquired CD57. Most importantly, NKG2C(+) NK cells transplanted from seropositive donors exhibit heightened function in response to a secondary CMV event compared with NKG2C(+) NK cells from seronegative donors. We conclude that NKG2C(+) memory-like NK cells are transplantable and require active or latent (subclinical) expression of CMV Ag in the recipient for clonal expansion of NK cells previously exposed to CMV in the donor. |
| | |
Authors:
|
Bree Foley; Sarah Cooley; Michael R Verneris; Julie Curtsinger; Xianghua Luo; Edmund K Waller; Claudio Anasetti; Daniel Weisdorf; Jeffrey S Miller |
Related Documents
:
|
23568529 - Kynurenine 3-monooxygenase mediates inhibition of th17 differentiation via catabolism o... 23721329 - T cell responses after hematopoietic stem cell transplantation for aggressive relapsing... 12778169 - Therapeutic stem and progenitor cell transplantation for organ vascularization and rege... 23313049 - C6-ceramide in combination with transforming growth factor-β enhances treg cell differ... 23166489 - Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells. 23600509 - Establishment and characterization of a novel anti-dnam-1 monoclonal antibody. 10720189 - Connective tissue-type mast cell leukemia in a dog. 11933149 - Cytotoxic activity of amooranin and its derivatives. 1248859 - Heterogeneity among preparations of crude trypsin used to disaggregate the human tonsil. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-17 |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 189 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-05 Completed Date: 2013-01-15 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 5082-8 Citation Subset: AIM; IM |
Affiliation:
|
Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antigens, CD57 / immunology Antigens, Viral / immunology* Cells, Cultured Cytomegalovirus / immunology*, metabolism Cytomegalovirus Infections / immunology*, therapy Female Hematologic Neoplasms / immunology, therapy* Humans Immunologic Memory* Killer Cells, Natural / immunology*, metabolism, transplantation Male NK Cell Lectin-Like Receptor Subfamily C* Peripheral Blood Stem Cell Transplantation* Transplantation, Homologous Up-Regulation / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
P01 CA065493/CA/NCI NIH HHS; P01 CA111412/CA/NCI NIH HHS; P01-CA111412/CA/NCI NIH HHS; P01-CA65493/CA/NCI NIH HHS; P30 CA077598/CA/NCI NIH HHS; P30-CA77598/CA/NCI NIH HHS; U10HL069294/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD57; 0/Antigens, Viral; 0/KLRC2 protein, human; 0/NK Cell Lectin-Like Receptor Subfamily C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein Kinase C-? Clustering at Immunological Synapses Amplifies Effector Responses in NK Cells.
Next Document: Stimulation of Human EBV- and CMV-Specific Cytolytic Effector Function Using Allogeneic HLA Molecule...