Document Detail


Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction.
MedLine Citation:
PMID:  22719221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating miRNAs have been shown as promising biomarkers for various pathologic conditions. The aim of this study was to clarify that circulating miR-1 and miR-126 in human plasma might be useful as biomarkers in acute myocardial infarction (AMI). In our study, after pre-test, two candidate miRNAs were detected by using real-time RT-PCR. Cardiac troponin I (cTnI) concentrations were measured by ELISA assay in plasma from patients with AMI (n=17) and healthy subjects (n=25), simultaneously. Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. A remarkable finding in this study is that miR-1, miR-126 and cTnI expression levels exhibited the same trend. Our results suggest that the plasma concentrations of miR-1 and miR-126 may be useful indicators for AMI.
Authors:
Guangwen Long; Feng Wang; Quanlu Duan; Fuqiong Chen; Shenglan Yang; Wei Gong; Yan Wang; Chen Chen; Dao Wen Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-07
Journal Detail:
Title:  International journal of biological sciences     Volume:  8     ISSN:  1449-2288     ISO Abbreviation:  Int. J. Biol. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-21     Completed Date:  2012-10-25     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101235568     Medline TA:  Int J Biol Sci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  811-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Female
Humans
Male
MicroRNAs / blood*
Middle Aged
Myocardial Infarction / blood*
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Biological Markers; 0/MIRN1 microRNA, human; 0/MIRN126 microRNA, human; 0/MicroRNAs
Comments/Corrections
Comment In:
Int J Biol Sci. 2012;8(10):1418-9   [PMID:  23197938 ]

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