| Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo galactosyl-oligosaccharides. | |
| | |
MedLine Citation:
|
PMID: 21880719 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Plasmacytoid dendritic cells (pDC) are specialized in the production of type I interferon (type I IFN), which promotes antiviral and anti-tumor responses, as well as autoimmune disorders. Activation of type I IFN secretion depends on the pattern recognition receptors TLR7 and TLR9, which sense microbial RNA and DNA respectively. Type I IFN production is modulated by several receptors, including the type II C-type lectin domain family 4, member C (CLEC4C). The natural ligand of CLEC4C is unknown. To identify it, here we probed a glycan array with a soluble form of the CLEC4C ectodomain. We found that CLEC4C recognizes complex type sugars with terminal galactose. Importantly, soluble CLEC4C bound peripheral blood leukocytes and tumor cells that express glycans with galactose residues at the non reducing ends. The positive and negative modulation of galactose residues on cell membranes was paralleled by the regulation of type I IFN secretion by pDC in co-culture experiments, in vitro. These results suggest that the modulation in the expression of non-sialylated oligosaccharides by invading pathogens or transformed cells may affect type I IFN response and immune surveillance. |
| | |
Authors:
|
Elena Riboldi; Roberta Daniele; Carmen Parola; Antonio Inforzato; Phoebe L Arnold; Daniela Bosisio; Daved H Freemont; Antonio Bastone; Marco Colonna; Silvano Sozzani |
Related Documents
:
|
8869669 - Release of cytokines and proteases from human peripheral blood mononuclear and polymorp... 15021969 - Functional interactions between mucosal il-1, il-ra and tgf-beta 1 in ulcerative colitis. 9700679 - Indomethacin attenuates oxytocin and hypothalamic-pituitary-adrenal axis responses to s... 10743969 - Nitric oxide inhibits aggrecan degradation in explant cultures of equine articular cart... 7763539 - Isolation and characterization of a novel immunomodulating fraction from soybeans. 1592209 - Cytokine regulation of endothelial cell function. 15350459 - The endothelium and early immune activation: new perspective and interactions. 19781989 - Role of nf-kappab activation in intestinal immune homeostasis. 21809139 - Evaluation of the phenotype pattern of macrophages isolated from malignant and non-mali... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-31 |
Journal Detail:
|
Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Universita' degli Studi di Brescia, Italy; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biochemical studies and ligand bound structures of biphenyl dehydrogenase from Pandoraea pnomenusa s...
Next Document: 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress duri...