| Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling. | |
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MedLine Citation:
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PMID: 21447704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: C-reactive protein (CRP) expression is increased with metabolic alterations. We sought to clarify the effect of CRP on the development of obesity-induced metabolic disorders using human CRP-overexpressing transgenic mice (CRPTG). METHODS AND RESULTS: CRPTG and their non-transgenic littermates (CON) were fed a standard diet (STD) or a high-fat diet (HFD) from 6 weeks of age. Oral glucose tolerance and intraperitoneal insulin tolerance tests 12 weeks after starting the diets showed deterioration of glucose tolerance and insulin sensitivity in HFD/CRPTG compared with HFD/CON. Hepatocellular ballooning, oil droplets, and peri-sinusoidal fibrosis were more prominent in HFD/CRPTG than in HFD/CON. In HFD/CRPTG, hepatic triglyceride content was higher and serum adiponectin levels lower than in HFD/CON. Epididymal adipose tissue mRNA expression of mucin-like, hormone receptor-like 1, monocyte chemotactic protein-1, and tumour necrosis factor-α in HFD/CRPTG was up-regulated compared with that in HFD/CON. Immunohistochemical staining of epididymal adipose tissue showed that the number of Mac-3(+) macrophages was higher in HFD/CRPTG than in HFD/CON. CONCLUSION: Human CRP overexpression facilitated the development of insulin resistance and hepatosteatosis with HFD in association with adiponectin down-regulation and enhancement of macrophage infiltration and expression of pro-inflammatory cytokines in epididymal adipose tissue, suggesting its pathogenic role in the development of obesity-induced metabolic disorders. |
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Authors:
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Hidehiro Kaneko; Toshihisa Anzai; Toshiyuki Nagai; Atsushi Anzai; Toshiyuki Takahashi; Yoshinori Mano; Kohkichi Morimoto; Yuichiro Maekawa; Hiroshi Itoh; Tsutomu Yoshikawa; Satoshi Ogawa; Keiichi Fukuda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-29 |
Journal Detail:
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Title: Cardiovascular research Volume: 91 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-20 Completed Date: 2011-11-23 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 546-55 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adipose Tissue / metabolism* Animals Biological Markers / blood Blood Glucose / metabolism Body Weight C-Reactive Protein / genetics, metabolism* Disease Models, Animal Fatty Liver / genetics, metabolism*, physiopathology Gene Expression Regulation Glucose Intolerance / genetics, metabolism*, physiopathology Glucose Tolerance Test Hemodynamics Humans Insulin / blood Insulin Resistance JNK Mitogen-Activated Protein Kinases / metabolism Lipids / blood Liver / metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Obesity / complications, genetics, metabolism*, physiopathology Organ Size Serum Amyloid A Protein / metabolism Time Factors Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Adipoq protein, mouse; 0/Biological Markers; 0/Blood Glucose; 0/Insulin; 0/Lipids; 0/Serum Amyloid A Protein; 9007-41-4/C-Reactive Protein; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases |
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