Document Detail


Human C-reactive protein (CRP) 1059G/C polymorphism.
MedLine Citation:
PMID:  10721674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We found a novel G-->C change at nucleotide 1059 within exon 2 of the CRP gene encoding the C-reactive protein. The CRP 1059G/C polymorphism could be detected by digestion with endonuclease MaeIII. The frequency of the CRP 1059C allele was 0.109 in Caucasians, but it was absent from Canadian Oji-Cree. Because of the importance of the CRP gene product in inflammation and its recent association with ischemic heart disease syndromes, this polymorphism may be useful in the association studies of atherosclerosis and its related phenotypes.
Authors:
H Cao; R A Hegele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human genetics     Volume:  45     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2000  
Date Detail:
Created Date:  2000-04-14     Completed Date:  2000-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  100-1     Citation Subset:  IM    
Affiliation:
Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, London, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Asian Continental Ancestry Group / genetics
C-Reactive Protein / genetics*
Canada
Chromosomes, Human, Pair 1
Coronary Disease / complications,  genetics
DNA Mutational Analysis
Diabetes Complications
Diabetes Mellitus / genetics
European Continental Ancestry Group / genetics
Female
Humans
Male
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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