| Human C-reactive protein (CRP) 1059G/C polymorphism. | |
| | |
MedLine Citation:
|
PMID: 10721674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We found a novel G-->C change at nucleotide 1059 within exon 2 of the CRP gene encoding the C-reactive protein. The CRP 1059G/C polymorphism could be detected by digestion with endonuclease MaeIII. The frequency of the CRP 1059C allele was 0.109 in Caucasians, but it was absent from Canadian Oji-Cree. Because of the importance of the CRP gene product in inflammation and its recent association with ischemic heart disease syndromes, this polymorphism may be useful in the association studies of atherosclerosis and its related phenotypes. |
| | |
Authors:
|
H Cao; R A Hegele |
Related Documents
:
|
9709214 - Identification of atlantic salmon (salmo salar) and rainbow trout (oncorhynchus mykiss)... 11334974 - A new multiplex pcr strategy for the simultaneous determination of four genetic polymor... 8095964 - Determination by pcr-rflp of apo e genotype in a japanese population. 10970384 - Characterization of the mycobacterium bovis restriction fragment length polymorphism dn... 891004 - Chromosomal anomalies in patients with retinoblastoma. 11490304 - Frequently deleted loci on chromosome 9 may harbor several tumor suppressor genes in hu... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of human genetics Volume: 45 ISSN: 1434-5161 ISO Abbreviation: J. Hum. Genet. Publication Date: 2000 |
Date Detail:
|
Created Date: 2000-04-14 Completed Date: 2000-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 100-1 Citation Subset: IM |
Affiliation:
|
Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, London, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alleles Asian Continental Ancestry Group / genetics C-Reactive Protein / genetics* Canada Chromosomes, Human, Pair 1 Coronary Disease / complications, genetics DNA Mutational Analysis Diabetes Complications Diabetes Mellitus / genetics European Continental Ancestry Group / genetics Female Humans Male Pedigree Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
|
9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human hepatocyte nuclear factor-1 beta (HNF1B) 1968A/G polymorphism.
Next Document: A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplas...