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Human Brain Arteriovenous Malformations are Associated with Interruptions in Elastic Fibers and Changes in Collagen Content.
MedLine Citation:
PMID:  23344861     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: We hypothesized that the loss of structural integrity in vessels of brain arteriovenous malformations (bAVM) is associated with abnormal expression of collagen subtypes. MATERIAL and
METHODS: We retrospectively obtained the nidus tissue specimens from 24 bAVM patients and structurally normal cerebral cortex from six surgical epilepsy patients. The samples were paraffin-embedded and stained with Victoria blue and picrosirius red and examined by light microscopy.
RESULTS: Light microscopy showed that collagen fibers became disorganized, and the internal elastic lamina was duplicated or interrupted in the arteries from the nidus tissue of bAVM. In some vessels in the nidus, Col I was the only collagen component and the interstitial tissue was mainly comprised of Col I. bAVM patients showed significantly higher Col I levels (86.25% ±13.92) and lower Col III levels (13.75% ±13.92) in the vasculature in the nidus tissue than those of otherwise normal surgical epilepsy patients (Col I, 80.78% ±18.03; Col III, 19.22% ±18.03) (p < 0.001). Additionally, bAVM patients showed a higher Col I / Col III ratio (24.71±40.47) than that of normal controls (16.04 ±31.28) (p < 0.001).
CONCLUSION: bAVM patients exhibit changes in the Col I/Col III ratio and elastic fibers in the vasculature, which may compromise the structural integrity of cerebral vessels.
Authors:
Yi Guo; Shi-Wei Qumu; Osman Arikan Nacar; Jin-Yan Yang; Jiang DU; Deniz Belen; Lin Pan; Yuan-Li Zhao
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  23     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  10-5     Citation Subset:  IM    
Affiliation:
Capital Medical University, Beijing Tiantan Hospital, Department of Neurosurgery, Beijing, China.
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