Document Detail


Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney.
MedLine Citation:
PMID:  11302728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl(-)/HCO(-)(3) exchanger located on the apical membrane of beta-intercalated kidney cells.
Authors:
M D Parker; E P Ourmozdi; M J Tanner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  282     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-16     Completed Date:  2001-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1103-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF336127;  AF336237
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Motifs / genetics
Anion Transport Proteins*
Antiporters / genetics*,  metabolism
Bicarbonates / metabolism
Cell-Free System
Chloride-Bicarbonate Antiporters*
Chromosomes, Human, Pair 20 / genetics
Chromosomes, Human, Pair 5 / genetics
Cloning, Molecular
Glycosylation
Humans
Ion Pumps / genetics,  metabolism
Kidney / metabolism*
Molecular Sequence Data
Multigene Family
Organ Specificity
Physical Chromosome Mapping
Protein Biosynthesis
Sequence Homology, Amino Acid
Sodium-Bicarbonate Symporters
Chemical
Reg. No./Substance:
0/Anion Transport Proteins; 0/Antiporters; 0/Bicarbonates; 0/Chloride-Bicarbonate Antiporters; 0/Ion Pumps; 0/SLC4A11 protein, human; 0/SLC4A9 protein, human; 0/Sodium-Bicarbonate Symporters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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