Document Detail


Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23.
MedLine Citation:
PMID:  11873941     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.
Authors:
Hiroyuki Nomoto; Toshitaka Oohashi; Satoshi Hirakawa; Yasuyoshi Ueki; Hiroshi Ohtsuki; Yoshifumi Ninomiya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Okayama     Volume:  56     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-03-04     Completed Date:  2002-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine and Dentistry, Japan.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Chromosomes, Human, Pair 1*
Dinucleotide Repeats
Humans
In Situ Hybridization, Fluorescence
Lectins, C-Type
Linkage (Genetics)
Multigene Family / genetics
Nerve Tissue Proteins / genetics*
Polymorphism, Genetic
Proteochondroitin Sulfates / genetics
Proteoglycans / genetics*
Chemical
Reg. No./Substance:
0/HAPLN2 protein, human; 0/Lectins, C-Type; 0/Nerve Tissue Proteins; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 155981-63-8/brevican

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