Document Detail


Human blood dendritic cell antigen 3 (BDCA3)(+) dendritic cells are a potent producer of interferon-λ in response to hepatitis C virus.
MedLine Citation:
PMID:  23213063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Human BDCA3(+) DCs, having a tendency to accumulate in the liver, recognize HCV in a CD81-, endosome-, and TRIF-dependent manner and produce substantial amounts of IL-28B/IFN-λ3, the ability of which is superior in subjects with IL-28B major genotype.
Authors:
Sachiyo Yoshio; Tatsuya Kanto; Shoko Kuroda; Tokuhiro Matsubara; Koyo Higashitani; Naruyasu Kakita; Hisashi Ishida; Naoki Hiramatsu; Hiroaki Nagano; Masaya Sugiyama; Kazumoto Murata; Takasuke Fukuhara; Yoshiharu Matsuura; Norio Hayashi; Masashi Mizokami; Tetsuo Takehara
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1705-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, Surface / metabolism*
Carcinoma, Hepatocellular / metabolism,  pathology
Cell Line, Tumor
Cells, Cultured
Dendritic Cells / drug effects,  metabolism*,  pathology
Female
Genotype
Hepacivirus / physiology*
Humans
Immunity, Innate / physiology
Interferon-gamma / metabolism*
Interleukins / metabolism
Leukocytes, Mononuclear / metabolism*,  pathology
Liver / metabolism*,  pathology
Liver Neoplasms / metabolism,  pathology
Male
Phenotype
Poly I-C / pharmacology
Chemical
Reg. No./Substance:
0/Antigens, Surface; 0/IL28B protein, human; 0/Interleukins; 0/blood dendritic cell antigen 3, human; 24939-03-5/Poly I-C; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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