| Human atrial natriuretic peptide ameliorates LPS-induced acute lung injury in rats. | |
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MedLine Citation:
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PMID: 20376471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute lung injury, a common component of systemic inflammatory disease, is a life-threatening condition without many effective treatments. However, recent studies have demonstrated that the multifunctional human atrial natriuretic peptide (hANP) exerts anti-inflammatory effects. Therefore, we tested the hypothesis that hANP could prevent lipopolysaccharide (LPS)-induced acute lung injury in a rodent model. Rats received an LPS injection and continuous intravenous infusion (CIV) of hANP or saline solution. We evaluated the anti-inflammatory effects of hANP by histological examination and determination of serum cytokine levels and lung myeloperoxidase (MPO) activity. Histological examination revealed marked reductions in interstitial congestion, edema, inflammation, and hemorrhage in lung tissue harvested 12 h after hANP treatment compared with tissue from rats that received saline treatment after LPS. LPS injection induced elevated cytokine (IL-1beta and IL-6) secretion and lung MPO activity, which was also attenuated by hANP treatment. Taken together, these data demonstrate that hANP exerts an anti-inflammatory effect and may have potential as a therapeutic agent to treat systemic inflammatory diseases. |
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Authors:
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Hironori Koga; Satoshi Hagiwara; Chihiro Shingu; Shigekiyo Matsumoto; Isao Yokoi; Takayuki Noguchi |
Publication Detail:
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Type: Journal Article Date: 2010-04-08 |
Journal Detail:
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Title: Lung Volume: 188 ISSN: 1432-1750 ISO Abbreviation: Lung Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: 241-6 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka-Hasamamachi, Yufu City, Oita, 879-5593, Japan. h.koga@med.oita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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drug therapy*,
pathology Animals Atrial Natriuretic Factor / administration & dosage, therapeutic use* Humans Infusions, Intravenous Interleukin-1beta / blood Interleukin-6 / blood Lipopolysaccharides Male Peroxidase / analysis Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Interleukin-6; 0/Lipopolysaccharides; 85637-73-6/Atrial Natriuretic Factor; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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