| Human Alzheimer and inflammation biomarkers after anesthesia and surgery. | |
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MedLine Citation:
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PMID: 21857497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls for additional study of the interaction between surgical care and Alzheimer neuropathology. The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery. METHODS: Eleven patients undergoing idiopathic nasal CSF leak correction were admitted to this Institutional Review Board-approved study. Lumbar subarachnoid catheters were placed before the procedure. Anesthesia was total intravenous propofol or remifentanil or inhalational sevoflurane, depending on provider choice. CSF samples were taken after catheter placement (base), at procedure end (0 h), and then at 6, 24, and 48 h. CSF was analyzed using xMAP Luminex immunoassay (Luminex, Austin, TX). RESULTS: Of the 11 patients (age range, 53 ± 6 yr), 8 were women; 4 received intravenous anesthesia, 6 sevoflurane, and 1 mixed. Procedures lasted 6.4 ± 2 h. Mean CSF amyloid-β(1-42) remained unchanged, but total-tau and phosphorylated-tau181P increased progressively until at least 48 h. Total-tau, phosphorylated-tau, or amyloid-β(1-42) concentrations were not different between anesthetic groups. CSF interleukin-10, S100Beta, and tumor necrosis factor α were increased similarly in both anesthetic groups at 24 h, but interleukin-6 was increased more in the inhalational group. CONCLUSION: These data indicate a robust neuroinflammatory response, including not only the usual markers (interleukin-6, tumor necrosis factor α, interleukin-10), but also S100Beta and tau, markers of injury. The total-tau/amyloid-β(1-42) ratio increased in a pattern consistent with Alzheimer disease, largely because of an increase in total-tau rather than a decline in amyloid-β(1-42). The differences in CSF interleukin-6 concentrations suggest that anesthetic management may make a difference in neuroinflammatory response. |
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Authors:
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Junxia X Tang; Dimitry Baranov; Mary Hammond; Leslie M Shaw; Maryellen F Eckenhoff; Roderic G Eckenhoff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 115 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-22 Completed Date: 2011-11-15 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 727-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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cerebrospinal fluid,
metabolism* Amyloid beta-Peptides / cerebrospinal fluid Anesthesia* Anesthesia, Inhalation Anesthesia, Intravenous Antibodies / analysis Biological Markers / analysis*, cerebrospinal fluid Enzyme-Linked Immunosorbent Assay Female Humans Immunoassay Inflammation / cerebrospinal fluid, metabolism* Interleukin-10 / cerebrospinal fluid Interleukin-6 / cerebrospinal fluid Male Middle Aged Peptide Fragments / cerebrospinal fluid Postoperative Period* S100 Proteins / cerebrospinal fluid Tumor Necrosis Factor-alpha / cerebrospinal fluid tau Proteins / cerebrospinal fluid |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG031742-04/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Antibodies; 0/Biological Markers; 0/Interleukin-6; 0/Peptide Fragments; 0/S100 Proteins; 0/Tumor Necrosis Factor-alpha; 0/amyloid beta-protein (40-1); 0/tau Proteins; 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
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