Document Detail


Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance.
MedLine Citation:
PMID:  14990555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that there is an association between the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism with the variability in exercise heat tolerance in humans. Fifty-eight Caucasian men were exposed to a 2-h exercise heat-tolerance test. We analyzed the association between their heat-tolerance levels with the ACE DD (n = 25) and I+ (n = 33) genotypes and with various anthropometrical parameters and aerobic fitness. It was found that the relative changes in body core temperature, heat storage, and heart rate during the 120-min exposure to exercise heat stress was consistently lower in the I+ genotype group compared with the DD genotype group (0.8 +/- 0.2 vs. 1 +/- 0.1 degrees C, P < 0.05; 17.7 +/- 1.8 vs. 19.8 +/- 1.3 W/M(2), P < 0.05; and 33 +/- 7 vs. 44 +/- 5 beats/min, respectively, P = 0.06). No significant association was found between heat strain response and the anthropometrical measurements or aerobic fitness in the various genotype groups. We suggest that the ACE I+ polymorphism may be considered as a possible candidate marker for increased heat tolerance.
Authors:
Yuval Heled; Daniel S Moran; Liran Mendel; Arie Laor; Elon Pras; Yair Shapiro
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2004-02-27
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  97     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-28     Completed Date:  2004-12-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Affiliation:
Heller Institute of Medical Research, Tel Aviv University, Tel Hashomer 52621, Israel. yheled@sheba.health.gov.il
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Anthropometry
Body Composition / physiology
Body Temperature Regulation / physiology
Exercise / physiology*
Heat Stress Disorders / enzymology,  genetics
Hot Temperature / adverse effects*
Humans
Isoenzymes / genetics,  physiology
Male
Peptidyl-Dipeptidase A / genetics*,  physiology
Polymorphism, Genetic / genetics*,  physiology
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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