| Hughes syndrome (the antiphospholipid syndrome): 25 years old. | |
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MedLine Citation:
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PMID: 18317878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiphospholipid (Hughes) syndrome (APS) is a unique thrombotic disorder, causing both arterial and venous thrombosis, linked to the presence of antibodies directed against phospholipid-protein complexes. The first papers describing the syndrome were published in 1983 and, over the next two years, a series of publications described in detail the various clinical manifestations of the syndrome. Laboratory standardisation workshops were also set up and, in 1984, the first "world" symposium on APS was held. The international APS conferences have continued to grow in numbers and in stature. The APS has already had an impact in obstetrics, in medicine, in psychiatry, and in surgery. The approximate figure of 1 in 5 is a useful guide -- 1 in 5 of all young strokes, 1 in 5 recurrent miscarriages, 1 in 5 DVTs. More precise data will become available in the worlds of epilepsy, migraine, Alzheimer's, and MS. The advent of newer "biologic" immunosuppressives such as rituximab may offer help in selected cases. Intravenous immunoglobulin has proved successful, especially in the emergency setting. |
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Authors:
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C J Edwards; G R V Hughes |
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Publication Detail:
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Type: Historical Article; Journal Article; Review Date: 2008-03-04 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: 18 ISSN: 1439-7595 ISO Abbreviation: Mod Rheumatol Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: Japan |
Other Details:
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Languages: eng Pagination: 119-24 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Southampton University Hospitals, Southampton, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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etiology Adult Antiphospholipid Syndrome* / complications, drug therapy, history, physiopathology Female History, 20th Century History, 21st Century Humans Pregnancy Stroke / etiology |
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