Document Detail

Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells.
MedLine Citation:
PMID:  18036348     Owner:  NLM     Status:  MEDLINE    
The FK506-binding protein 38 (FKBP38) is a pro-apoptotic regulator of Bcl-2 in neuroblastoma cells. Hsp90 inhibits the pro-apoptotic FKBP38/CaM/Ca(2+) complex and thus prevents interactions between FKBP38 and Bcl-2. Here we show that Hsp90 increases cell survival rates of neuroblastoma cells after apoptosis induction. Depletion of FKBP38 by short interference RNA significantly decreased the anti-apoptotic effect of Hsp90 expression. In addition, the influence of high cellular Hsp90 levels was only observed in post-stimulation apoptosis that is sensitive to selective FKBP38 active site inhibition. Similar anti-apoptotic effects in neuroblastoma cells were observed after stimulation of endogenous Hsp90 expression. Hence, the inhibition of FKBP38 by Hsp90 participates in programmed cell death control of neuroblastoma cells.
Frank Erdmann; Franziska Jarczowski; Matthias Weiwad; Gunter Fischer; Frank Edlich
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Publication Detail:
Type:  Journal Article     Date:  2007-11-26
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5709-14     Citation Subset:  IM    
Max-Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D-06120, Halle/Saale, Germany.
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MeSH Terms
Binding Sites
Calcium / metabolism
Calmodulin / metabolism
Cell Death
Cell Line, Tumor
HSP90 Heat-Shock Proteins / metabolism*
Iodoacetic Acid / pharmacology
Neuroblastoma / metabolism*
Tacrolimus Binding Proteins / antagonists & inhibitors*,  metabolism
Reg. No./Substance:
0/Calmodulin; 0/HSP90 Heat-Shock Proteins; 64-69-7/Iodoacetic Acid; 7440-70-2/Calcium; EC 5.2.1.-/Tacrolimus Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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