Document Detail

Hsp60 and human aging: Les liaisons dangereuses.
MedLine Citation:
PMID:  23276948     Owner:  NLM     Status:  MEDLINE    
Stressors can cause abnormal intracellular accumulation of Hsp60 and its localization in extramitochondrial sites, secretion, and circulation, with immune system activation. Dysfunction of chaperones associated with their quantitative and qualitative decline with aging (chaperonopathies of aging) characterizes senescence and is a potential causal factor in the physiological deterioration that occurs with it. The role of Hsp60 in aging is not easy to elucidate, because aging is accompanied by pathologies (e.g., cardiovascular and neurodegenerative disorders, osteoporosis, diabetes, cancer, etc.) in which Hsp60 has been implicated but, although those disorders are more frequent in the elderly, they are not unique to them. Therefore, it is difficult to determine what is due to aging and what to an associated disease that can occur regardless of age. Does Hsp60 contribute to the pathogenesis? How and when does Hsp60 interact with the immune system and, thus, contributes to the initiation-progression of the generalized chronic inflammation characteristic of aging? These and related issues are discussed here in the light of reports showing the participation of Hsp60 in aging-associated disorders.
Francesco Cappello; Everly Conway de Macario; Antonella Marino Gammazza; Giuseppe Bonaventura; Francesco Carini; Anna M Czarnecka; Felicia Farina; Giovanni Zummo; Alberto J L Macario
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-37     Citation Subset:  IM    
Department of Experimental Biomedicine and Clinical Neurosciences, Human Anatomy Section, Emerico Luna, Via del Vespro 129, 90127 Palermo, Italy.
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MeSH Terms
Aging / physiology
Arthropathy, Neurogenic / physiopathology
Atherosclerosis / physiopathology
Autoantibodies / physiology
Cell Aging / physiology
Chaperonin 60 / chemistry,  immunology,  physiology*
Heart Failure / physiopathology
Immune System / physiology
Mitochondria / physiology
Mitochondrial Proteins / chemistry,  immunology,  physiology*
Neurodegenerative Diseases / physiopathology
Reg. No./Substance:
0/Autoantibodies; 0/Chaperonin 60; 0/HSPD1 protein, human; 0/Mitochondrial Proteins

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