Document Detail

Is Hsp27 a marker of myocardial ischaemia?
MedLine Citation:
PMID:  19838950     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heat shock protein (Hsp) 27 expression in cardiomyocytes increases in response to ischaemia. The extracellular release of Hsp27 from cardiomyocytes is proportional to its intracellular levels.
AIM: To assess the influence of significant coronary artery disease (CAD), which by definition results in chronic myocardial ischaemia, on blood serum levels of Hsp27.
METHODS: Blood serum levels of Hsp27 in 62 patients with at least 50% lumen diameter narrowing in at least one main epicardial coronary artery on angiography and in 21 controls with normal coronaries were measured.
RESULTS: Patients with CAD tended to have higher serum level of Hsp27 than controls [0.463 (0.158-0.809) vs. 0.184 (0.099-0.337) ng/ml, p = 0.084]. Serum Hsp27 level in patients with CAD affecting more than a single vessel was significantly increased [0.529 (0.192-1.004) ng/ml] compared with controls (p = 0.035) and with one artery narrowed [0.276 (0.087-0.549) ng/ml, p = 0.041]. No correlation between Hsp27 serum levels and severity of coronary narrowings assessed by Gensini score was found (r = 0.21, p = 0.11).
CONCLUSIONS: Serum level of Hsp27 seems to be a potential marker of myocardial ischaemia caused by advanced 2- or 3-vessel CAD.
Grazyna Józefowicz-Okonkwo; Karina Wierzbowska-Drabik; Marek Kasielski; Ewa Trzos; Anna Goraca; Dariusz Nowak; Jarosław Kasprzak; Maria Krzemińska-Pakuła
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kardiologia polska     Volume:  67     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-01-26     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  947-52     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Chronic Disease
Coronary Angiography
Coronary Circulation
HSP27 Heat-Shock Proteins / metabolism*
Middle Aged
Myocardial Ischemia / blood*,  diagnosis
Myocytes, Cardiac / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/HSP27 Heat-Shock Proteins; 0/HSPB1 protein, human
Comment In:
Kardiol Pol. 2009 Sep;67(9):953-4   [PMID:  19938353 ]

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