| Is Hsp27 a marker of myocardial ischaemia? | |
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MedLine Citation:
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PMID: 19838950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Heat shock protein (Hsp) 27 expression in cardiomyocytes increases in response to ischaemia. The extracellular release of Hsp27 from cardiomyocytes is proportional to its intracellular levels. Aim: To assess the influence of significant coronary artery disease (CAD), which by definition results in chronic myocardial ischaemia, on blood serum levels of Hsp27. METHODS: Blood serum levels of Hsp27 in 62 patients with at least 50% lumen diameter narrowing in at least one main epicardial coronary artery on angiography and in 21 controls with normal coronaries were measured. RESULTS: Patients with CAD tended to have higher serum level of Hsp27 than controls [0.463 (0.158-0.809) vs. 0.184 (0.099-0.337) ng/ml, p = 0.084]. Serum Hsp27 level in patients with CAD affecting more than a single vessel was significantly increased [0.529 (0.192-1.004) ng/ml] compared with controls (p = 0.035) and with one artery narrowed [0.276 (0.087-0.549) ng/ml, p = 0.041]. No correlation between Hsp27 serum levels and severity of coronary narrowings assessed by Gensini score was found (r = 0.21, p = 0.11). CONCLUSIONS: Serum level of Hsp27 seems to be a potential marker of myocardial ischaemia caused by advanced 2- or 3-vessel CAD. |
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Authors:
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Grazyna J??zefowicz-Okonkwo; Karina Wierzbowska-Drabik; Marek Kasielski; Ewa Trzos; Anna Goraca; Dariusz Nowak; Jaros??aw Kasprzak; Maria Krzemi??ska-Paku??a |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kardiologia polska Volume: 67 ISSN: 0022-9032 ISO Abbreviation: Kardiol Pol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376352 Medline TA: Kardiol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 947-52 Citation Subset: IM |
Affiliation:
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Medical University, Lodz, Poland. gokonkwo@zdn.umed.lodz.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Chronic Disease Coronary Angiography Coronary Circulation Female HSP27 Heat-Shock Proteins / metabolism* Humans Male Middle Aged Myocardial Ischemia / blood*, diagnosis Myocytes, Cardiac / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/HSP27 Heat-Shock Proteins; 0/HSPB1 protein, human |
| Comments/Corrections | |
Comment In:
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Kardiol Pol. 2009 Sep;67(9):953-4
[PMID:
19938353
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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