Document Detail

Hsp10: anatomic distribution, functions, and involvement in human disease .
MedLine Citation:
PMID:  23277031     Owner:  NLM     Status:  In-Data-Review    
There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and secretory granules, alone or in combination with other proteins. In these extramitochondrial locales, Hsp10 plays an active role in cell signalling. For example, cancer cells often show altered levels of Hsp10, compared to normal cells. Hsp10 may also be found in the extracellular space and in the bloodstream, with a possible immunomodulatory activity. This minireview focuses on some studies to date on the involvement of Hsp10 in human disease pathogenesis.
Sabrina David; Fabio Bucchieri; Simona Corrao; Anna M Czarnecka; Claudia Campanella; Felicia Farina; Giovanni Peri; Giovanni Tomasello; Carmelo Sciumè; Giuseppe Modica; Giampiero La Rocca; Rita Anzalone; Mario Giuffrè; Everly Conway de Macario; Alberto Jl Macario; Francesco Cappello; Giovanni Zummo
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  768-78     Citation Subset:  IM    
Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Italy, via del Vespro 143.
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