| Hoyomycolic acid, a novel mycolic acid species with an unusual structure that defines a new Actinobacteria genus. | |
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MedLine Citation:
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PMID: 22194354 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Corynebacterineae are characterized by the presence of long-chain lipids, notably mycolic acids (α-alkyl, β-hydroxy fatty acids), the structures of which are genus-specific. Mycolic acids from two environmental strains, Amycolicicoccus subflavus and Hoyosella altamirensis, were isolated and their structures established using a combination of mass spectrometry analysis, 1H-NMR spectroscopy and chemical degradations. The C2-C3 cleavage of these C30-C36 acids led to 2 fragments: saturated C9-C11 acids and saturated and unsaturated C20-C25 aldehydes. Surprisingly, the fatty acids at the origin of the two fragments constitutive of these mycolic acids were present only minute amounts in the fatty acid pool. Moreover, the double bond in the main C24 aldehyde fragment was located at ω16 position, whereas that found in the ethylenic fatty acids of the bacteria is at ω9. These data question the biosynthesis of these new mycolic acids in terms of nature of the precursors, chain elongation and desaturation. Nevertheless, they are consistent with the occurrence of the key genes of mycolic acid biosynthesis, including those encoding proteins of the fatty acid synthase II system, identified in the genome of A. subflavus. Altogether, while the presence of mycolic acids and analysis of their 16S rDNA sequences would suggest the belonging of the strains to the Mycobacteriaceae family, the originality of their structures reinforces the novelty of the recently described Amycolicicoccus and Hoyosella genera. |
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Authors:
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Marie-Antoinette Lanéelle; Anne Launay; Lucie Spina; Hedia Marrakchi; Françoise Laval; Nathalie Eynard; Anne Lemassu; Maryelle Tropis; Mamadou Daffé; Gilles Etienne |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
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Title: Microbiology (Reading, England) Volume: - ISSN: 1465-2080 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430468 Medline TA: Microbiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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IPBS, Université Paul Sabatier, Toulouse, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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