| Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. | |
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MedLine Citation:
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PMID: 15634706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Hoxa2 transcription factor acts during development of the second branchial arch. As for most of the developmental processes controlled by Hox proteins, the mechanism by which Hoxa2 regulates the morphology of second branchial arch derivatives is unclear. We show that Six2, another transcription factor, is genetically downstream of Hoxa2. High levels of Six2 are observed in the Hoxa2 loss-of-function mutant. By using a transgenic approach to overexpress Six2 in the embryonic area controlled by Hoxa2, we observed a phenotype that is reminiscent of the Hoxa2 mutant phenotype. Furthermore, we demonstrate that Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region. These results strongly suggest that Six2 is a direct target of Hoxa2. |
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Authors:
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Eva Kutejova; Bettina Engist; Moisés Mallo; Benoît Kanzler; Nicoletta Bobola |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-01-05 |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 132 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-03-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 469-78 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Max-Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Branchial Region / embryology, metabolism Down-Regulation* Gene Expression Regulation, Developmental* Head / embryology Homeodomain Proteins / genetics, metabolism* Mesoderm / cytology, metabolism* Mice Mice, Transgenic Molecular Sequence Data Mutation / genetics Neural Crest / cytology, embryology*, metabolism* Phenotype Promoter Regions, Genetic / genetics RNA, Messenger / genetics, metabolism Transcription Factors / chemistry, genetics, metabolism* Up-Regulation / genetics |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Hoxa2 protein, mouse; 0/RNA, Messenger; 0/Six2 protein, mouse; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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