| The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. | |
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MedLine Citation:
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PMID: 1685889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the isolation and expression pattern of a novel mouse homeobox gene, Hox-4.8. Hox-4.8 is the most 5'-located homeobox gene in the HOX-4 complex. Sequence analysis confirmed that Hox-4.8 is a member of the subfamily of AbdominalB-related Hox-4 genes and revealed strong interspecies conservation. As for the human locus, Hox-4.8 is probably the last Hox gene in this part of the HOX-4 complex. During development, Hox-4.8 transcripts are restricted to the extremities of the embryonic anteroposterior axis and limbs as well as in the developing tail bud and to the most posterior segment of the gut (the rectum). Within the limb mesenchyme, Hox-4.8 is expressed in more posterodistal regions than those of its neighbour Hox-4.7. Hence, Hox-4.8 expression appears to be related to the last significant phenotypic changes towards the extremities of the embryonic body and limb axes. |
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Authors:
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P Dollé; J C Izpisúa-Belmonte; E Boncinelli; D Duboule |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mechanisms of development Volume: 36 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-03-16 Completed Date: 1992-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 3-13 Citation Subset: IM |
Affiliation:
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European Molecular Biology Laboratory, Heidelberg, Germany. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/S78378; S78944; S78945; S78946; S78947; S78948; S78949; S78950; S80553; X63719 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA DNA-Binding Proteins / genetics Drosophila Embryonic and Fetal Development / genetics Forelimb / embryology Gene Expression Genes, Homeobox / genetics* Hindlimb / embryology Homeodomain Proteins* Humans Mice Mice, Inbred BALB C Molecular Sequence Data RNA Probes Restriction Mapping Sequence Homology, Nucleic Acid Transcription Factors* |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/HOXD13 protein, human; 0/Homeodomain Proteins; 0/Hoxd13 protein, mouse; 0/RNA Probes; 0/Transcription Factors; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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