Document Detail

How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease?
MedLine Citation:
PMID:  7781454     Owner:  NLM     Status:  MEDLINE    
Twenty-four normal subjects and 64 symptomatic patients with various degrees of reflux disease (24 with reflux symptoms without esophagitis and 21 with mild and 19 with severe esophagitis) underwent quantitative 24-hr intraesophageal pH monitoring. Various reflux parameters during supine, interprandial, and postprandial periods were examined by binary logistic regression and by CART analysis to determine the sensitivity and specificity to separate the various groups of subjects and patients. The distinction was excellent between asymptomatic controls and patients with severe erosive esophagitis (sensitivity and specificity both 100% by logistic regression and 95% and 88%, respectively, by CART), but discrimination was poor when asymptomatic controls were compared to symptomatic patients without esophagitis (71% and 79% by logistic regression and 75% and 92% by CART), which is the most important indication for pH recording in clinical practice. A 3-hr postprandial pH recording was inadequate to distinguish the various groups. The acidity of the reflux episodes during the night appeared to be a crucial factor in the development of severe erosive esophagitis. The duration of esophageal acid exposure was another important factor in the development of reflux lesions.
G Ghillebert; A M Demeyere; J Janssens; G Vantrappen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  40     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-19     Completed Date:  1995-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1317-24     Citation Subset:  AIM; IM    
Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Aged, 80 and over
Circadian Rhythm / physiology*
Esophagus / physiopathology*
Gastroesophageal Reflux / diagnosis*,  physiopathology
Hydrogen-Ion Concentration
Logistic Models
Middle Aged
Monitoring, Physiologic / instrumentation,  methods,  statistics & numerical data
Multivariate Analysis
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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