Document Detail


How we are born.
MedLine Citation:
PMID:  20364092     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human reproduction is relatively inefficient. Nearly 30% of pregnancies result in spontaneous losses, which are both a clinical problem and a psychological stress to the families involved. Furthermore, although the human population is growing rapidly and is predicted to reach 9 billion by 2050, 15% of couples worldwide are childless because of infertility. Many underlying causes of infertility have been overcome by assisted reproductive technologies such as in vitro fertilization, yet pregnancy success rates using such approaches remain disappointingly low. Since mechanistic approaches to study human reproductive processes are ethically restricted, future advances in fertility treatment and the development of new contraceptives rely predominantly on the study of the factors influencing reproduction in model systems. The articles in this Reproductive Biology Review series present updates on the current understanding of various reproductive processes in model systems and raise questions that need to be addressed if we are to improve human reproductive health.
Authors:
Sudhansu K Dey
Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-04-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  952-5     Citation Subset:  AIM; IM    
Affiliation:
Cincinnati Children's Research Foundation, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. sk.dey@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryo Implantation
Female
Humans
Male
Placenta / physiology
Pregnancy
Reproduction / physiology*
Sperm-Ovum Interactions
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