Document Detail


How vision and movement combine in the hippocampal place code.
MedLine Citation:
PMID:  23256159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
How do external environmental and internal movement-related information combine to tell us where we are? We examined the neural representation of environmental location provided by hippocampal place cells while mice navigated a virtual reality environment in which both types of information could be manipulated. Extracellular recordings were made from region CA1 of head-fixed mice navigating a virtual linear track and running in a similar real environment. Despite the absence of vestibular motion signals, normal place cell firing and theta rhythmicity were found. Visual information alone was sufficient for localized firing in 25% of place cells and to maintain a local field potential theta rhythm (but with significantly reduced power). Additional movement-related information was required for normally localized firing by the remaining 75% of place cells. Trials in which movement and visual information were put into conflict showed that they combined nonlinearly to control firing location, and that the relative influence of movement versus visual information varied widely across place cells. However, within this heterogeneity, the behavior of fully half of the place cells conformed to a model of path integration in which the presence of visual cues at the start of each run together with subsequent movement-related updating of position was sufficient to maintain normal fields.
Authors:
Guifen Chen; John A King; Neil Burgess; John O'Keefe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-19
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-02-27     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Evoked Potentials / physiology
Hippocampus / physiology*
Male
Mice
Mice, Inbred C57BL
Motion Perception / physiology*
Movement / physiology*
Neurons / metabolism*
Orientation / physiology*
Photic Stimulation
Reward
Space Perception / physiology*
Theta Rhythm / physiology
Vision, Ocular / physiology*
Grant Support
ID/Acronym/Agency:
095811//Wellcome Trust; G1000854//Medical Research Council; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
E78ZFF4KQ0/Reward
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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