| How viral oncogenes make the cell cycle. | |
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MedLine Citation:
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PMID: 8763499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oncogenic viruses provide their host cells with additional growth stimuli, thereby extending their proliferative capacity. This implies that viral oncogenes can override growth-suppressive signals, which control cell-cycle progression in untransformed cells. Viral oncoproteins deregulate cell-cycle control by interfering with receptor-mediated signal transduction pathways and the function of nuclear cell-cycle regulatory proteins. As a consequence of these regulatory interactions, many viral oncogenes induce the expression of cellular genes required for cell-cycle progression, including genes encoding G1 cyclins. Apparently, different oncogenic viruses target different subsets of these cell-cycle regulatory pathways to transform cells. |
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Authors:
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P Jansen-Dürr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in genetics : TIG Volume: 12 ISSN: 0168-9525 ISO Abbreviation: Trends Genet. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-09 Completed Date: 1996-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8507085 Medline TA: Trends Genet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 270-5 Citation Subset: IM |
Affiliation:
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Deutsches Krebsforschungszentrum, Forschungs-schwerpunkt Angewandte Tumorvirologie, Heidelberg, Germany. p.jansen-duerr@dkfz-beidelberg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Cell Division Cell Transformation, Viral Cyclins / biosynthesis Gene Expression Regulation, Viral Genes, cdc Oncogene Proteins, Viral / physiology Oncogenic Viruses / growth & development, physiology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Cyclins; 0/Oncogene Proteins, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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