Document Detail

How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude?
MedLine Citation:
PMID:  20376057     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Although B-type natriuretic peptide (BNP) concentrations seem to be useful for detecting the presence of patent ductus arteriosus, there is no information about their usefulness for monitoring changes in PDA shunt magnitude.
STUDY DESIGN: We performed a retrospective analysis of paired BNP-echocardiogram measurements (obtained from infants (24 to 32 weeks gestation) with clinical suspicion of PDA).
RESULT: Individual BNP concentrations (n=146, from 88 infants) were significantly related to shunt magnitude at the time of measurement and had good discriminating power for detecting a moderate-or-large shunt (area under receiver-operator characteristic curves (ROC-AUC)=0.85). In total, 36 infants had serial BNP-echocardiogram pairs (n=91) measured during their hospitalization. Changes (either increases or decreases) in BNP concentrations over time had only fair discriminating power (ROC-AUC=0.76) for detecting increases or decreases, respectively, in shunt magnitude.
CONCLUSION: The high degree of variability in the BNP measurements made them less useful for monitoring changes in magnitude.
S Chen; T Tacy; R Clyman
Related Documents :
17977527 - Healing properties of malabaricone b and malabaricone c, against indomethacin-induced g...
8237357 - Asymptomatic reopening of ductus arteriosus after successful closure by indomethacin in...
19159727 - Analysis of outcome in 298 extremely low-birth-weight infants with patent ductus arteri...
20584797 - Is cerebral oxygen supply compromised in preterm infants undergoing surgical closure fo...
1437437 - Milk production by mothers of premature infants: influence of cigarette smoking.
6781857 - The effect of 2% co2, 100% o2, theophylline and 15% o2 on "inspiratory drive" and "effe...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-04-08
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  780-5     Citation Subset:  IM    
Department of Pediatrics, University of California-San Francisco, 513 Parnassus Ave., San Francisco, CA 94143-0544, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determinants of female sexual dysfunction in type 2 diabetes.
Next Document:  Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants.