Document Detail


How ubiquitin functions with ESCRTs.
MedLine Citation:
PMID:  21722280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endosomal-sorting complex required for transport (ESCRT) apparatus has multiple ubiquitin (Ub)-binding domains and participates in a wide variety of cellular processes. Many of these ESCRT-dependent processes are keenly regulated by Ub, which serves as a lysosomal-sorting signal for membrane proteins targeted into multivesicular bodies (MVBs) and which may serve as a mediator of viral budding from the cell surface. Hints that both ESCRTs and Ub work together in the processes such as cytokinesis, transcription and autophagy are beginning to emerge. Here, we explore the relationship between ESCRTs and Ub in MVB sorting and viral budding.
Authors:
S Brookhart Shields; Robert C Piper
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-07-27
Journal Detail:
Title:  Traffic (Copenhagen, Denmark)     Volume:  12     ISSN:  1600-0854     ISO Abbreviation:  Traffic     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2012-02-06     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  100939340     Medline TA:  Traffic     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1306-17     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Animals
Endosomal Sorting Complexes Required for Transport / genetics,  metabolism,  physiology*
Protein Binding
Protein Transport
Ubiquitin / genetics,  metabolism,  physiology*
Viral Proteins / metabolism*
Virus Release / physiology*
Grant Support
ID/Acronym/Agency:
2R01GM058202-13/GM/NIGMS NIH HHS; 5T32DK007690-19/DK/NIDDK NIH HHS; R01 GM058202/GM/NIGMS NIH HHS; R01 GM058202-13/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Endosomal Sorting Complexes Required for Transport; 0/Ubiquitin; 0/Viral Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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