| How I treat acute and chronic leukemia in pregnancy. | |
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MedLine Citation:
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PMID: 18472198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of pregnancy associated leukemia is approximately 1 case out of 10,000 pregnancies. This rare occurrence precludes the conducting of large, prospective studies to examine diagnostic, management and outcome issues. The treatment of a pregnant woman with leukemia may be associated with severe adverse fetal outcome including death and malformations, and therefore poses a difficult challenge for both the patient and the attending physician. Chemotherapy during the 1st trimester is associated with an increased risk for congenital malformations. However, this risk diminishes as pregnancy advances. When acute leukemia is diagnosed during the 1st trimester, patients should be treated promptly similar to non-pregnant patients. However, the aggressive induction therapy should follow pregnancy termination. When the diagnosis is made later in pregnancy standard chemotherapy regimen should be considered and usually pregnancy termination is not mandatory. However, both the mother and the fetus should be under close observation and delivery should be postponed to a non-cytopenic period. Pregnancy associated chronic myelogenous leukemia (CML) can be treated with interferon throughout pregnancy with no apparent increase in adverse fetal outcome. In the very rare case of chronic lymphocytic leukemia (CLL) during pregnancy treatment can usually be delayed until after delivery. |
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Authors:
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Tal Shapira; David Pereg; Michael Lishner |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-05-09 |
Journal Detail:
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Title: Blood reviews Volume: 22 ISSN: 0268-960X ISO Abbreviation: Blood Rev. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708558 Medline TA: Blood Rev Country: Scotland |
Other Details:
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Languages: eng Pagination: 247-59 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine A, Meir Hospital, Sapir Medical Center, Kfar-Sava, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Adolescent Adult Antineoplastic Agents / adverse effects* Child Child, Preschool Female Humans Infant Leukemia / complications, drug therapy* Pregnancy Pregnancy Complications, Neoplastic / drug therapy* Pregnancy Trimesters Prenatal Exposure Delayed Effects* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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