| How to treat Helicobacter pylori infection--should treatment strategies be based on testing bacterial susceptibility? A personal viewpoint. | |
| | |
MedLine Citation:
|
PMID: 8853263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peptic ulcer disease is an infectious disease. Only antibiotic regimens that achieve a 90% cure should be used to treat this infection. Antimicrobial susceptibility is the main determinant in the success of therapy; cure rates are usually lower in resistant strains. As in any other infectious disease it is essential in treatment studies to stratify results according to pretreatment bacterial susceptibility. Cure-rates have to be reported separately for sensitive and resistant strains. It must be realized that a study achieving a high cure rate with a certain regimen can either have included few patients with resistant strains or, alternatively, the regimen tested can have a high efficacy in resistant strains. This issue is fundamental and only if that information is available, do we know whether or not we can reproduce the results reported in that particular study in a different population. We have reviewed all Helicobacter studies that tested pretreatment bacterial susceptibility. The results achieved with dual therapy, bismuth triple therapy, proton pump inhibitor triple therapy and quadruple therapy in sensitive and resistant strains are discussed. Based on these data, treatment recommendations are made for empirical treatment in areas with low resistance rates and those with high resistance rates. If treatment is individualized and based on the antibiogram then easier, shorter and cheaper regimens seem possible. |
| | |
Authors:
|
W A de Boer; G N Tytgat |
Related Documents
:
|
20822623 - Microbiology of acute complicated bacterial sinusitis at the university of the witwater... 15837383 - Identification of an essential glycoprotease in staphylococcus aureus. 6370053 - Elimination of plasmidic resistance to ampicillin and of enterotoxinogenicity in certai... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: European journal of gastroenterology & hepatology Volume: 8 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 1996 Jul |
Date Detail:
|
Created Date: 1996-12-26 Completed Date: 1996-12-26 Revised Date: 2009-10-16 |
Medline Journal Info:
|
Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 709-16 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Sint Anna Hospital, Oss, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
therapeutic use Anti-Ulcer Agents / therapeutic use Drug Therapy, Combination / therapeutic use Helicobacter Infections / drug therapy* Helicobacter pylori / drug effects* Humans Microbial Sensitivity Tests Peptic Ulcer / microbiology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Haemochromatosis presenting with loss of libido and impotence.
Next Document: Ca2+ signalling in cultured smooth muscle cells from human bladder.