Document Detail

How to manage patients with need for antiplatelet therapy in the setting of (un-)planned surgery.
MedLine Citation:
PMID:  18853094     Owner:  NLM     Status:  MEDLINE    
The growing incidence of cardiovascular diseases leads to an increase in patients who require treatment with antiplatelet drugs. About 5% of patients who underwent a percutaneous coronary intervention will have to undergo surgery within the first year. In these patients the problem evolves how to handle the antiplatelet therapy in the perioperative period. A continuation of these drugs in order to reduce cardiovascular events is associated with increased perioperative bleeding. Withdrawing antiplatelet agents in order to reduce surgical hemorrhage leads to a significant increase of cardiovascular morbidity and mortality, especially in patients who have been treated with implantation of drug eluting stents. This review balances the specific risks of either approach and offers an algorithm how to manage patients in need for antiplatelet therapy in the setting of (un-)planned surgery.
Helge Möllmann; Holger M Nef; Christian W Hamm; Albrecht Elsässer
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-13
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  98     ISSN:  1861-0692     ISO Abbreviation:  -     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  8-15     Citation Subset:  IM    
Dept. of Cardiology, Kerckhoff Heart Center, Benekestrasse 2-8, 61231, Bad Nauheim, Germany.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Cardiovascular Diseases / drug therapy*,  surgery
Drug-Eluting Stents
Hemorrhage / chemically induced
Intraoperative Complications / chemically induced
Perioperative Care / methods
Platelet Aggregation Inhibitors / adverse effects,  therapeutic use*
Risk Assessment
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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