Document Detail

How to make beta cells?
MedLine Citation:
PMID:  19781928     Owner:  NLM     Status:  MEDLINE    
Insulin-producing beta cells are lost or insufficient in diabetic patients, presenting the medical challenge for new beta cells. Currently, there are three strategies that offer promise. One involves the generation of beta cells de novo by directing the differentiation of either embryonic stem cells or induced pluripotent cells to the beta cell lineage. The second is based on the conversion of another terminally differentiated cell to beta cells in a process called reprogramming. The third approach is to promote the replication of existing beta cells either in vivo or in vitro. Significant progress is evident for each strategy, but it remains unclear which approach will ultimately prove successful.
Malgorzata Borowiak; Douglas A Melton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-09-24
Journal Detail:
Title:  Current opinion in cell biology     Volume:  21     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-02     Completed Date:  2010-03-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-32     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation*
Cell Lineage
Cell Proliferation
Diabetes Mellitus / metabolism,  therapy
Embryonic Stem Cells / cytology
Insulin-Secreting Cells / cytology*
Models, Biological
Pluripotent Stem Cells / cytology,  metabolism
Signal Transduction
Grant Support
U01 DK072505/DK/NIDDK NIH HHS; //Howard Hughes Medical Institute

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