Document Detail


How to keep proliferative neural stem/progenitor cells: a critical role of asymmetric inheritance of cyclin D2.
MedLine Citation:
PMID:  22895110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has long been argued that cell cycle regulators such as cyclins, cyclin-dependent kinases and their inhibitors affect the fate of neuronal progenitor cells. Recently, we identified that cyclin D2, which localizes at the basal tip of the radial glial cell (i.e., the neural progenitor in the developing neocortex), functions to give differential cell fates to its daughter cells just after cell division. This basally biased localization is due to transportation of cyclin D2 mRNA via its unique cis-regulatory sequence and local translation into cyclin D2 protein at the basal endfoot. During division of the neural progenitor cells, cyclin D2 protein is inherited by the daughter cell that retain the basal process, resulting in asymmetric distribution of cyclin D2 protein between the two daughter cells. Cyclin D2 is similarly localized in the human fetal cortical primordium, suggesting a common mechanism for the maintenance of neural progenitors and a possible scenario in evolution of primate brains. Here we introduce our recent findings and discuss how cyclin D2 functions in mammalian brain development and evolution.
Authors:
Yuji Tsunekawa; Noriko Osumi
Publication Detail:
Type:  Journal Article     Date:  2012-08-16
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-02-26     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3550-4     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution
Brain / embryology,  metabolism
Cell Proliferation
Cyclin D2 / genetics*,  metabolism*
Gene Expression Regulation, Developmental
Humans
Inheritance Patterns / genetics*
Mammals / embryology,  metabolism
Models, Biological
Neural Stem Cells / cytology*,  metabolism*
Chemical
Reg. No./Substance:
0/Cyclin D2
Comments/Corrections

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