| How to halve ploidy: lessons from budding yeast meiosis. | |
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MedLine Citation:
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PMID: 22481439 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans. |
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Authors:
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Gary William Kerr; Sourav Sarkar; Prakash Arumugam |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-6 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: - ISSN: 1420-9071 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK, g.w.kerr@warwick.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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