Document Detail


How to find your way through the thymus: a practical guide for aspiring T cells.
MedLine Citation:
PMID:  21842411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thymocytes must complete an elaborate developmental program in the thymus to ultimately generate T cells that express functional but neither harmful nor useless TCRs. Each developmental step coincides with dynamic relocation of the thymocytes between anatomically discrete thymic microenvironments, suggesting that thymocytes' migration is tightly regulated by their developmental status. Chemokines produced by thymic stromal cells and chemokine receptors on the thymocytes play an indispensable role in guiding developing thymocytes into the different microenvironments. In addition to long-range migration, chemokines increase the thymocytes' motility, enhancing their interaction with stromal cells. During the past several years, much progress has been made to determine the various signals that guide thymocytes on their journey within the thymus. In this review, we summarize the progress in identifying chemokines and other chemoattractant signals that direct intrathymic migration. Furthermore, we discuss the recent advances of two-photon microscopy in determining dynamic motility and interaction behavior of thymocytes within distinct compartments to provide a better understanding of the relationship between thymocyte motility and development.
Authors:
Ivan Dzhagalov; Hyewon Phee
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-14
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  69     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-10     Completed Date:  2012-03-27     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  663-82     Citation Subset:  IM    
Copyright Information:
© Springer Basel AG 2011
Affiliation:
LSA, Room 479, Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California Berkeley, Berkeley, CA 94720-3200, USA. ild@berkeley.edu
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MeSH Terms
Descriptor/Qualifier:
Cell Adhesion
Cell Communication
Cell Movement
Chemokines / metabolism
Humans
Signal Transduction
T-Lymphocytes / cytology,  immunology,  metabolism*
Thymocytes / cytology,  metabolism*
Grant Support
ID/Acronym/Agency:
K01 AR059754-01/AR/NIAMS NIH HHS; K01 AR059754-01/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Chemokines
Comments/Corrections

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