Document Detail

How to interpret thyroid biopsy results: a three-year retrospective interventional radiology experience.
MedLine Citation:
PMID:  19937026     Owner:  NLM     Status:  MEDLINE    
Results of thyroid biopsy determine whether thyroid nodule resection is appropriate and the extent of thyroid surgery. At our institution we use 20/22-gauge core biopsy (CBx) in conjunction with fine-needle aspiration (FNA) to decrease the number of passes and improve adequacy. Occasionally, both ultrasound (US)-guided FNA and CBx yield unsatisfactory specimens. To justify clinical recommendations for these unsatisfactory thyroid biopsies, we compare rates of malignancy at surgical resection for unsatisfactory biopsy results against definitive biopsy results. We retrospectively reviewed a database of 1979 patients who had a total of 2677 FNA and 663 CBx performed by experienced interventional radiologists under US guidance from 2003 to 2006 at a tertiary-care academic center. In 451 patients who had surgery following biopsy, Fisher's exact test was used to compare surgical malignancy rates between unsatisfactory and malignant biopsy cohorts as well as between unsatisfactory and benign biopsy cohorts. We defined statistical significance at P = 0.05. We reported an overall unsatisfactory thyroid biopsy rate of 3.7% (100/2677). A statistically significant higher rate of surgically proven malignancies was found in malignant biopsy patients compared to unsatisfactory biopsy patients (P = 0.0001). The incidence of surgically proven malignancy in unsatisfactory biopsy patients was not significantly different from that in benign biopsy patients (P = 0.8625). In conclusion, an extremely low incidence of malignancy was associated with both benign and unsatisfactory thyroid biopsy results. The difference in incidence between these two groups was not statistically significant. Therefore, patients with unsatisfactory biopsy specimens can be reassured and counseled accordingly.
Jason D Oppenheimer; Deepa Kasuganti; Ritu Nayar; Howard B Chrisman; Robert J Lewandowski; Albert A Nemcek; Robert K Ryu
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Publication Detail:
Type:  Journal Article     Date:  2009-11-24
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  33     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-5     Citation Subset:  IM    
Department of Radiology, Northwestern Medical Faculty Foundation, 676 North St Clair Street, Suite 800, Chicago, IL 60611, USA.
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MeSH Terms
Aged, 80 and over
Biopsy / methods
Biopsy, Fine-Needle / methods
Cohort Studies
Data Interpretation, Statistical
Middle Aged
Predictive Value of Tests
Radiology, Interventional / methods*
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Thyroid Gland / pathology*,  surgery,  ultrasonography
Thyroid Neoplasms / diagnosis*,  epidemiology,  surgery
Ultrasonography, Interventional / methods
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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