Document Detail


How to Analyze Mitochondrial Morphology in Healthy Cells and Apoptotic Cells in Caenorhabditis elegans.
MedLine Citation:
PMID:  24974287     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mitochondria constantly undergo fusion and fission events. A proper balance of fusion and fission is essential in healthy cells, as disrupting this balance is associated with several neurodegenerative diseases. Mitochondrial fission has also been shown to play an important role during apoptosis. Hence, the machineries that control mitochondrial morphology have both nonapoptotic and apoptotic functions. Seminal work in yeast has identified some of the key components of these machineries. However, the list is certainly not complete and new factors that are specific to metazoans are being identified every year. In this review, we describe methodologies to test whether a particular candidate gene plays a role in the control of mitochondrial morphology in healthy cells and apoptotic cells using Caenorhabditis elegans.
Authors:
Stéphane G Rolland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  544     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-98     Citation Subset:  IM    
Copyright Information:
© 2014 Elsevier Inc. All rights reserved.
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