Document Detail


How thiostrepton was made in the laboratory.
MedLine Citation:
PMID:  23208736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thiostrepton, a powerful antibiotic belonging to the thiopeptide class, was synthesized in the laboratory for the first time in 2004 through an arduous campaign involving novel strategies and tactics, scenic detours, and unexpected roadblocks. In this Review the author narrates the long journey to success, not so dissimilar to Odysseus' return voyage to Ithaca, full of adventure, knowledge, and wisdom.
Authors:
K C Nicolaou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-03
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  51     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-31     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  12414-36     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemical synthesis,  chemistry*
Aza Compounds / chemical synthesis,  chemistry
Crystallography, X-Ray
Molecular Conformation
Penicillins / chemical synthesis,  chemistry
Quinolines / chemistry
Thiostrepton / chemical synthesis,  chemistry*
Grant Support
ID/Acronym/Agency:
R01 AI055475/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Aza Compounds; 0/Penicillins; 0/Quinolines; HR4S203Y18/Thiostrepton; P90NWT719R/quinaldic acid
Comments/Corrections

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