Document Detail

How the skin can tell time.
MedLine Citation:
PMID:  19369933     Owner:  NLM     Status:  MEDLINE    
The mammalian central circadian pacemaker, which is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, synchronizes and entrains clocks found in peripheral tissues. Skin harbors an active circadian clock that is under the influence of the central clock. This clock, which probably operates in most-perhaps all-types of skin cells, may influence the regulation of several circadian physiological phenomena, including cell proliferation.
Mikhail Geyfman; Bogi Andersen
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1063-6     Citation Subset:  IM    
Departments of Medicine and Biological Chemistry, University of California, Irvine, California 92697, USA.
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MeSH Terms
Cell Proliferation
Circadian Rhythm / physiology*
Fibroblasts / cytology,  physiology
Keratinocytes / cytology*,  physiology
Models, Animal
Skin / cytology*
Skin Physiological Phenomena*
Suprachiasmatic Nucleus / physiology
Comment On:
J Invest Dermatol. 2009 May;129(5):1225-31   [PMID:  19037239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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