| How science will help shape future clinical applications of probiotics. | |
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MedLine Citation:
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PMID: 18181725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recent increased interest in probiotics among clinicians has many causes, primarily the concern about the limitations of the current armamentarium of pharmaceutical agents. Although probiotics have been used mostly in dietary supplements and foods to maintain health, scientific and clinical studies are recognizing the potential of some probiotics to be therapeutic in function. Scientific breakthroughs in understanding the source and composition of the human microbiota, the key nutritional factors that influence these microbes, and their immunomodulatory effects; the creation of disease-targeted recombinant strains; the isolation and characterization of signaling molecules that can modulate microbial biofilms and infectious processes; and advances in biomedical engineering that will provide new delivery systems for probiotics will shape the future of clinical applications of probiotics. In time and with rigorous documentation, some probiotics will likely find an important place in medical practice. |
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Authors:
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Gregor Reid |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 46 Suppl 2 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-09 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: S62-6; discussion S144-51 Citation Subset: IM |
Affiliation:
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Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. gregor@uwo.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biofilms / growth & development Biomedical Research / standards* Diarrhea / microbiology Diet Drug Delivery Systems Female Humans Intestines / microbiology Probiotics / therapeutic use* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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