| HOW SACRAL NERVE STIMULATION WORKS IN PATIENTS WITH FAECAL INCONTINENCE. | |
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MedLine Citation:
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PMID: 21689312 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: Sacral nerve stimulation (SNS) reduces incontinence episodes and improves the quality of life of patients treated for faecal incontinence. However, the exact mechanism of action of this technique remains unclear. The present article reviews the pertinent neuroanatomy and neurophysiology related to SNS and provides explanations for potential mechanisms of action. Method: A systematic review of the literature was performed for studies of the potential mechanisms of action of SNS, using MEDLINE, PubMed, Embase and the Cochrane Library. Articles dealing with the technique, adverse events and economic evaluations of SNS, as well as literature reviews, were excluded, except for reviews dealing with the mechanisms of action of SNS. The following inclusion criteria were used to select articles: (i) articles in English, (ii) randomized, double-blinded, sham-controlled studies, and (iii) cohort studies. Case-control studies or retrospective studies were cited only when randomized or cohort studies could not be found. Results: We propose three hypotheses to explain the mechanism of action of SNS: (i) a somato-visceral reflex, (ii) a modulation of the perception of afferent information, and (iii) an increase in external anal sphincter activity. Conclusion: The mechanism of action of SNS in patients with faecal incontinence almost certainly depends on the modulation of spinal and/or supraspinal afferent inputs. Further research on humans and animals will be required to gain a better understanding of the mechanisms of action of SNS. |
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Authors:
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G Gourcerol; V Vitton; Am Leroi; F Michot; A Abysique; M Bouvier |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-21 |
Journal Detail:
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Title: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Volume: - ISSN: 1463-1318 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-6-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883611 Medline TA: Colorectal Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 The Association of Coloproctology of Great Britain and Ireland. |
Affiliation:
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ADEN EA 3234/IFR MP 23, Physiology Unit, Rouen University Hospital, F-76031, France Gastroenterology Unit, Hôpital Nord, Marseille, France CRN2M, Neurogastroenterology Interface, UMR 6153 CNRS-Aix-Marseille University, France Digestive Surgery Unit, Rouen University Hospital, F-76031, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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