Document Detail


How often are endometrial polyps malignant in asymptomatic postmenopausal women? A multicenter study.
MedLine Citation:
PMID:  19027096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to evaluate the prevalence of cancer and premalignant lesions in polyps on atrophic endometrium in asymptomatic postmenopausal women to compare these findings with a similar cohort of patients with abnormal uterine bleeding. STUDY DESIGN: One thousand one hundred fifty-two asymptomatic and 770 consecutive postmenopausal women with abnormal uterine bleeding were included in a retrospective multicenter study. Recruited patients underwent hysteroscopic polypectomy based on a sonohysterographic or hysteroscopic diagnosis. The pathologic report was the main outcome measure. RESULTS: One single case of stage 1 grade 1 endometrial carcinoma on a polyp with a mean diameter of 40 mm (0.1%) was observed in asymptomatic women. This prevalence was 10 times lower than in symptomatic patients (P < .0001). The prevalence of atypical hyperplastic polyps was 1.2% in asymptomatic women (2.2% in symptomatic patients; P < .005). At multivariate analysis, polyps' diameter was the only variable significantly associated to an abnormal histology (cancer, polypoid cancer, and atypical hyperplasia) in asymptomatic women (odds ratio for polyps with mean diameter > 18 mm, 6.9; confidence interval, 2.2-21.4). CONCLUSION: Follow-up and/or treatment of endometrial polyps incidentally diagnosed in asymptomatic postmenopausal patients could be safely restricted to few selected cases based on polyp diameter.
Authors:
Enrico Ferrazzi; Errico Zupi; Francesco P Leone; Luca Savelli; Umberto Omodei; Massimo Moscarini; Maurizio Barbieri; Giuseppe Cammareri; Giampiero Capobianco; Ettore Cicinelli; Maria E Coccia; Gloria Donarini; Simona Fiore; Paolo Litta; Mario Sideri; Eugenio Solima; Donata Spazzini; Antonia C Testa; Massimo Vignali
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-11-21
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  200     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-03     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235.e1-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, DSC L. Sacco, University of Milan, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / epidemiology*,  pathology,  surgery
Aged
Endometrial Neoplasms / epidemiology*,  pathology,  surgery
Female
Follow-Up Studies
Humans
Hyperplasia
Hysteroscopy
Middle Aged
Neoplasms / epidemiology,  pathology,  surgery
Polyps / epidemiology*,  pathology,  surgery
Postmenopause*
Precancerous Conditions / epidemiology*,  pathology,  surgery
Prevalence
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metaanalysis vs large clinical trials: which should guide our management?
Next Document:  Transoral resection of thyroid cancer metastasis to retropharyngeal lymph node