Document Detail

How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish.
MedLine Citation:
PMID:  18075256     Owner:  NLM     Status:  MEDLINE    
We used transgenic zebrafish expressing GFP or YFP in subpopulations of neurons to study the migration, homing process and axon extension of groups of CNS neurons in different regions of the zebrafish brain. We found that extensive migration takes place at all levels of the CNS and gives rise to nuclei or cell populations with specific identities. Here, we describe 4 previously unknown or only partially characterized migratory events taking place in the zebrafish telencephalon and rhombic lip, using 3 different transgenic lines, and identify the phenotypes of the cells undertaking these migrations. The migration of a subgroup of mitral cell precursors from the dorsocaudal telencephalon to the olfactory bulb, visualized in the tg(tbr1:YFP) transgenic line, is coupled with morphogenetic transformation of the dorsal telencephalon. The tg(1.4dlx5a-6a:GFP) transgenic line provides a means to analyze the migration of GABAergic interneurons from the ventral to the dorsal telencephalon, thus extending the occurrence of this migration to another vertebrate. The tg(Xeom:GFP) transgenic line provides the first demonstration of the dorsoventral migration of glutamatergic septal neurons, present in mammals and now described in fish, thus reconciling the contrasting evidence of dorsal patterning genes (tbr1, eomes) expressed in a ventral cell population. Furthermore, migration studies in the tg(1.4dlx5a-6a:GFP) and tg(Xeom:GFP) lines help determine the origin of 2 important cell populations in the fish cerebellum: projection neurons and Purkinje cells. These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events.
Marina Mione; Danila Baldessari; Gianluca Deflorian; Gilda Nappo; Cristina Santoriello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental neuroscience     Volume:  30     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  65-81     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
IFOM, FIRC Institute of Molecular Oncology, Milan, Italy.
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MeSH Terms
Animals, Genetically Modified
Cell Differentiation / genetics
Cell Lineage / genetics
Cell Movement / physiology*
Central Nervous System / cytology,  embryology*,  physiology
Gene Expression Regulation, Developmental / genetics
Morphogenesis / physiology*
Neurons / cytology,  physiology*
Stem Cells / cytology,  physiology*
Zebrafish / embryology*,  physiology
Grant Support
//Wellcome Trust

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