Document Detail

How much tachycardia in infants can be attributed to fever?
MedLine Citation:
PMID:  15159699     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: We evaluate the hypothesis that pulse rate increases linearly with increased body temperature in infants and determine how much tachycardia in infants can be explained by a 1 degrees C (1.8 degrees F) increase in body temperature. METHODS: Infants younger than 1 year and presenting to a pediatric emergency department were prospectively enrolled. Rectal temperature and pulse rate were measured. Research personnel rated behavioral state as sleeping, awake and quiet, fussy, or crying. Patients were excluded if they were fussy or crying or if they had any medical condition expected to cause tachycardia. The remaining patients were divided into 6 age-based groups. Linear regression analysis of pulse rate and temperature was performed for each group. RESULTS: Four hundred ninety patients were enrolled. Pulse rate increased linearly with temperature in all age groups older than 2 months (adjusted r2=0.102 to 0.376) but not in infants younger than 2 months (adjusted r2=0.004). In infants aged 2 months or older, a multivariate linear regression model adjusted for age showed that pulse rate increased an average of 9.6 beats/min (95% confidence interval 7.7 to 11.5) per 1 degrees C (1.8 degrees F) increase in temperature (adjusted r2=0.225). At any given temperature, the prediction interval for an individual's pulse rate had a span of approximately 64 beats/min. CONCLUSION: In infants 2 to 12 months of age, pulse rate increases linearly with body temperature, with a mean increase of 9.6 beats/min for each 1 degrees C (1.8 degrees F) increase in body temperature. Pulse rates of individual infants vary greatly, however, with a broad range of pulse rates observed at any given temperature.
Colleen M Hanna; David S Greenes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  43     ISSN:  1097-6760     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-705     Citation Subset:  AIM; IM    
Division of Emergency Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Body Temperature / physiology*
Fever / complications*,  physiopathology
Heart Rate / physiology*
Infant, Newborn
Linear Models
Prospective Studies
Tachycardia / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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