| How much of the intraaortic balloon volume is displaced toward the coronary circulation? | |
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MedLine Citation:
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PMID: 20080266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: During intraaortic balloon inflation, blood volume is displaced toward the heart (V(tip)), traveling retrograde in the descending aorta, passing by the arch vessels, reaching the aortic root (V(root)), and eventually perfusing the coronary circulation (V(cor)). V(cor) leads to coronary flow augmentation, one of the main benefits of the intraaortic balloon pump. The aim of this study was to assess V(root) and V(cor) in vivo and in vitro, respectively. METHODS: During intraaortic balloon inflation, V(root) was obtained by integrating over time the aortic root flow signals measured in 10 patients with intraaortic balloon assistance frequencies of 1:1 and 1:2. In a mock circulation system, flow measurements were recorded simultaneously upstream of the intraaortic balloon tip and at each of the arch and coronary branches of a silicone aorta during 1:1 and 1:2 intraaortic balloon support. Integration over time of the flow signals during inflation yielded V(cor) and the distribution of V(tip). RESULTS: In patients, V(root) was 6.4% +/- 4.8% of the intraaortic balloon volume during 1:1 assistance and 10.0% +/- 5.0% during 1:2 assistance. In vitro and with an artificial heart simulating the native heart, V(cor) was smaller, 3.7% and 3.8%, respectively. The distribution of V(tip) in vitro varied, with less volume displaced toward the arch and coronary branches and more volume stored in the compliant aortic wall when the artificial heart was not operating. CONCLUSION: The blood volume displaced toward the coronary circulation as the result of intraaortic balloon inflation is a small percentage of the nominal intraaortic balloon volume. Although small, this percentage is still a significant fraction of baseline coronary flow. |
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Authors:
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Christina Kolyva; George M Pantalos; John R Pepper; Ashraf W Khir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 140 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-08-12 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 110-6 Citation Subset: AIM; IM |
Copyright Information:
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2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Brunel Institute for Bioengineering, Brunel University, Middlesex, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiopathology* Blood Pressure Blood Volume* Compliance Computer Simulation Coronary Circulation* Female Humans Intra-Aortic Balloon Pumping* Male Middle Aged Models, Anatomic Models, Cardiovascular Regional Blood Flow Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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PG/06/120//British Heart Foundation |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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