| How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view. | |
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MedLine Citation:
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PMID: 12020162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antimalarial mechanism of qinghaosu (artemisinin) has been a problem since the late 1970s. During the past decade, several molecular level theories were postulated. However, their further development has been very difficult. By looking into the QHS cleavage process and all possible reaction paths available to the resulting transient radicals, the present commentary reveals those major hidden problems with the existing theories and tries to identify some essential features of the parasiticidal events that may take place within the intraerythrocytic malaria parasite. A seemingly more reasonable theory is also introduced. |
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Authors:
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Yikang Wu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Accounts of chemical research Volume: 35 ISSN: 0001-4842 ISO Abbreviation: Acc. Chem. Res. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-21 Completed Date: 2003-04-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0157313 Medline TA: Acc Chem Res Country: United States |
Other Details:
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Languages: eng Pagination: 255-9 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 354 Fenglin Road, Shanghai 200032, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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chemistry*,
metabolism,
pharmacology Artemisinins / chemistry*, metabolism, pharmacology Free Radicals / pharmacology Models, Biological Sesquiterpenes / chemistry*, metabolism, pharmacology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 0/Free Radicals; 0/Sesquiterpenes; 63968-64-9/artemisinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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